WebThe expansion of trinucleotide repeats is known to cause a growing number of human diseases. However, the mechanism and timing of expansions are poorly understood. Recent studies indicate that expansion mutations occur by multiple pathways during both meiotic and mitotic divisions, and at various stages of cell division. WebThe expansion of trinucleotide repeat (TNR) sequences in human DNA is considered to be a key factor in the pathogenesis of more than 40 neurodegenerative diseases. TNR expansion occurs during DNA replication and also, as suggested by recent studies, during the repair of DNA lesions produced by oxidative stress.
Trinucleotide Repeat - an overview ScienceDirect Topics
WebApr 19, 2024 · A trinucleotide repeat is a sequence of three DNA building blocks (nucleotides) that is repeated a number of times in a row. DNA segments with an abnormal number of these repeats are unstable and prone to errors during cell division. The number of repeats can change as the gene is passed from parent to child. WebHuntington’s Disease (HD) is an inherited neurodegenerative disease that is caused by a CAG trinucleotide repeat expansion in the huntingtin (HTT) gene. This mutation produces a dysfunctional protein that aggregates and causes degeneration of GABAergic neurons in the striatum, which is a brain region that contributes to movement and cognition. cinemark theater fort collins co
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Trinucleotide repeat disorders, also known as microsatellite expansion diseases, are a set of over 50 genetic disorders caused by trinucleotide repeat expansion, a kind of mutation in which repeats of three nucleotides (trinucleotide repeats) increase in copy numbers until they cross a threshold above which they become unstable. Depending on its location, the unstable trinucleotide repeat may cause defects in a protein encoded by a gene; change the regulation of gene expression; prod… WebNational Center for Biotechnology Information WebTrinucleotide Repeat Expansion Medicine & Life Sciences 100%. Trinucleotide Repeats Medicine & Life Sciences 90%. DNA Structure Chemical Compounds 78%. Glutamine … diabetology course chennai