Web5 Dec 2024 · To determine the significance of TRF2 recruitment to damage sites, the effects of TRF2 depletion were examined using cell-based assays for different pathways of DSB repair (Hu and Parvin, 2014). TRF2 was depleted for 48 h before repair assays in order to minimize telomere erosion, which was typically assayed 4–7 days after depletion ( … WebTRF1-interacting nuclear protein 2 (TIN2), encoded by the TERF1-interacting nuclear factor 2 (TINF2) gene, is part of the shelterin complex and interacts with the shelterin factors TRF1, TRF2, and TPP1. Mutations in TINF2 cause DC and more rarely HH. So far, most of the mutations identified are de novo (and consequently autosomal dominant) and ...
The Basic Domain of TRF2 Directs Binding to DNA Junctions …
WebNovák, Martin Fakulta: Fakulta informatiky Rok: 2014, studium úspěšně absolvováno, udělen titul: Mgr. Program/obor Aplikovaná informatika / Služby - výzkum, řízení a inovace Obhajoba diplomové práce: Best Practices in Scalable Web Development Práce na příbuzné téma WebTERF2 plays a central role in preventing ATM kinase DNA damage response. It binds telomeric dsDNA and prevents telomeres from activating ATM kinase. This interaction of … shsgamedesign.weebly.com
TRF2 Monoclonal Antibody (4A794.15) (MA1-41001) - Thermo Fisher Scientific
WebRequires Internet Explorer 8 or above: Forgot your password? Call 1-800-977-8943 Copyright© 2024 Sedgwick Privacy Policy Terms & Conditions Privacy Policy Web15 Jun 2024 · Telomeric repeat-binding factor 2 (TRF2) is a subunit of the shelterin protein complex, which binds to and protects telomeres from unwanted DNA damage response … WebTRF2 is the key protein in the formation and stabilization of t-loops [25], through its TRFH dimerization domain [41]. Deletion of shelterin complex components leads to the activation of two main DDR signaling pathways mediated by the ATM and ATR kinases [42]. shs forms