Web1 mar. 2024 · The conclusion is that vestibular damage can affect the sleep-wakefulness cycle of rats; the level of autophagy in hypothalamic tissue is upregulated and may affect cell proliferation and activity through mTOR-P13K/Akt, which has a certain reference value for tumor formation and provides a basis for the research of insomnia or sleep disorders … Web10 nov. 2024 · Treatment. Outlook. “Motor neuron disease” refers to a group of diseases that cause the motor nerves in the spine and brain to lose function over time. They are a …
mTOR in inflammatory skin diseases: Review of the literature
Since the discovery of mTOR, much research has been done on the subject, using rapamycin and rapalogs to understand its biological functions. The clinical results from targeting this pathway were not as straight forward as thought at first. Those results have changed the course of clinical research in this field. Initially, rapamycin was developed as an antifungal drug against Candida albic… WebAge-related diseases and mTOR. Several disorders have age as a risk factor, including neurodegenerative diseases (e.g. Parkinson’s disease [PD] and Alzheimer’s disease … hello fm kovai
Recent advances and limitations of mTOR inhibitors in the …
Web11 mar. 2024 · A recent rapamycin phase 1/2 clinical trial demonstrated improved disease activity in active SLE patients during 12 months of treatment . mTOR activation was … Web11 apr. 2024 · MND is a fatal, rapidly progressing disease that affects the brain and spinal cord. It attacks the nerves that control movement so muscles no longer work, leaving … WebmTOR in inflammatory skin diseases. It has been shown that the mTOR pathway is involved in the pathogenesis of several dermatological conditions such as epithelial tumors, melanoma, mycosis fungoides, sclerosis tuberose, psoriasis, acne, wound healing and recently hidradenitis suppurativa [5]. Regarding the immune system, mTOR showed to … hello fm coimbatore rj kannan