WebHOXBLINC loss attenuates NPM1c+-driven leukemogenesis by rectifying the signature of NPM1c+ leukemic transcription programs. Furthermore, overexpression of HoxBlinc (HoxBlincTg) in mice enhances HSC self-renewal and expands myelopoiesis, leading to the development of AML-like disease, reminiscent of the phenotypes seen in the Npm1 … WebHOXBLINC loss attenuates NPM1c + -driven leukemogenesis by rectifying the signature of NPM1c + leukemic transcription programs. Furthermore, overexpression of HoxBlinc (HoxBlincTg) in mice enhances HSC self-renewal and expands myelopoiesis, leading to the development of AML-like disease, reminiscent of the phenotypes seen in the Npm1 …
Frontiers LncRNA Functions as a New Emerging Epigenetic Factor …
WebHoxBlinc knockout downregulates the expression of HoxB gene and other cardiac/hematopoietic differentiation related genes and the components of the Notch signaling. In mechanism, HoxBlinc can bind to the HoxB genes and activated HoxB gene expression through recruiting the Setd1a/MLL1 complex and mediating long-range … Web5 Loss of HOXBLINC perturbs NPM1c+-mediated transcription programs and leukemogenesis. To confirm HOXBLINC activation is a downstream event of NPM1c+ and determine the role of HOXBLINC in NPM1c+-mediated transcription regulation and leukemogenesis, we performed RNA-seq analysis on LSK cells isolated from the Npm1 … how to go from molecules to moles
A novel leukemic route of mutant NPM1 through nuclear import …
Webchromatin structure. Mechanistically, HoxBlinc binds to the promoter regions of NPM1c+ signature genes to control their activation in HoxBlincTg HSPCs, via MLL1 recruitment … Web29 nov. 2024 · HoxBlinc is an anterior HoxB gene-associated intergenic lncRNA. It is a cis-acting lncRNA and functions as an epigenetic regulator to coordinate anterior HoxB gene … WebHOXBLINC loss attenuates NPM1c+-driven leukemogenesis by rectifying the signature of NPM1c+ leukemic transcription programs. Furthermore, overexpression of HoxBlinc … how to go from moles to molecule