Foxl2 c134w
WebTo gain insight into the process of labor and the effects of labor on placental gene expression, we performed a microarray analysis to identify the di… WebDec 16, 2024 · We previously studied the role of FOXL2 C134W, its partner SMAD3 and its antagonist FOXO1 in cellular models of aGCT. Methods In this work, seeking more comprehensive profiling of FOXL2 C134W transcriptomic effects, we performed an RNA-seq analysis comparing the effect of FOXL2 WT /SMAD3 and FOXL2 C143W /SMAD3 …
Foxl2 c134w
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WebMar 21, 2024 · The somatic missense point mutation c.402C>G (p.C134W) in the FOXL2 transcription factor is pathognomonic for adult-type granulosa cell tumours (AGCT) and a diagnostic marker for this tumour type. However, the molecular consequences of this mutation and its contribution to the mechanisms of AGCT pathogenesis remain unclear. … WebFeb 27, 2024 · FOXL2 is expressed in the ovarian granulosa cells (GCs) and plays a key role during the development of female reproduction system and in its maintenance [ 15, …
WebSep 2, 2024 · FOXL2 C134W induction is associated with distinct regulatory states. A, Bar plot displaying the number of enriched region called (left) and the enriched region …
WebJun 15, 2013 · The FOXL2C134W mutation has been identified in virtually all adult granulosa cell tumors (GCTs). Here we show that the exogenous FOXL2 expression is necessary for GDF-9 stimulation of follistatin transcription in the human GCT cell line, COV434 that lacks endogenous FOXL2 expression. WebIn the mammalian ovary cell growth and differentiation is regulated by several members of the transforming growth factor β (TGFβ) superfamily includin…
WebMay 22, 2024 · The presence of the FOXL2 C134W mutation provides a molecular diagnosis of aGCT which has proven helpful in resolving the diagnosis of aGCT in histologically ambiguous or problematic cases [70, 71, 72]. FOXL2 plays a fundamental and essential role in ovarian development; its biology has been extensively studied [78, 79, …
WebDOI: 10.1016/j.gyobfe.2008.06.026 Corpus ID: 879733 [Juvenile granulosa-cell tumor: clinical and molecular expression]. @article{Kalfa2009JuvenileGT, title={[Juvenile granulosa-cell tumor: clinical and molecular expression].}, author={Nicolas Kalfa and Pascal Philibert and Catherine Patte and Elisabeth Thibaud and Catherine Pienkowski and Aude … horsey mugsWebNov 1, 2024 · The FOXL2-C134W mutation is shared in all GCTs, and its downregulation of hormone-related apoptosis appears causal in induction of tumor phenotype. On these assumptions, hormone anti-estrogenic therapies have been proposed for recurrent GCTs. A 32-year-old woman suffering from GCT was first treated by surgery in 2004 and staged … pspla renewalWebWe confirmed an altered DNA binding specificity for FOXL2 C134W in vitro and identified unique targets of FOXL2 C134W including SLC35F2 whose expression increased sensitivity to YM155 in our model. horsey mill sealsWebJan 9, 2014 · C134W mutated FOXL2 has been shown to inhibit the activin and GDF-9 induction of anti-proliferative follistatin, which may lead to increased cell proliferation and tumor formation [15]. Activin and TGF-β signaling are mediated by SMAD3, an essential regulator of CCND2 (cyclin D2) promoter [16]. horsey mills mdWebAll four index GCTs had a missense point mutation, 402C→G (C134W), in FOXL2, a gene encoding a transcription factor known to be critical for granulosa-cell development. The FOXL2 mutation was... horsey mill norfolk seals horseyWebAuthor pages are created from data sourced from our academic… show more psplash-drmWebApr 23, 2024 · The FOXL2 C134W mutation is characteristic of adult granulosa cell tumors of the ovary. Jamieson S, Butzow R, Andersson N, Alexiadis M, Unkila-Kallio L, … psplash下载