Chloramphenicol slideshare
WebOral Dose The oral dosage for rapidly excreted tetracyclines, equivalent to tetracycline hydrochloride, is 0.25-0.5 g four times daily for adults and 20-40 mg/kg/d for children (12 years of age and Web(3) Chloramphenicol binds to 50S subunit—interferes with peptide bond formation and transfer of peptide chain from 'P' site. (4) Erythromycin and clindamycin also bind to 50S ribosome and hinder translocation of the elongated peptide chain back from 'A' site to 'P' site and the ribosome does not move along the mRNA to expose the next codon.
Chloramphenicol slideshare
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WebMar 3, 2024 · Chloramphenicol – Differences with Tetracycline • Highly effective against S. typhi (RESISTANT NOW) • More effective against H. influenzae, B. pertissis, N. menigitidis • Less active against gm+ve cocci and spirochaetes • Not effective against – chlamydia, entmoeba and plasmodia. 20. WebChloramphenicol diffuses into breast milk and readily crosses the placenta; fetal blood levels are 30–80% of maternal serum concentrations. Inactivation occurs primarily by hepatic glucuronidation. Hepatic insufficiency is known to decrease metabolism but rarely requires dose modification. Chloramphenicol has an elimination half-life of 1–4 ...
WebNov 13, 2024 · It was first Man made antibiotic. 4. Introduction Chloramphenicol is an Antibiotic. Chloramphenicol is useful for the treatment of a number of bacterial infections. It has broad spectrum antibiotic that typically stops bacterial growth by stopping the production of protein. 5. Characteristics Chloramphenicol is a yellowish white Crystalline Solid. WebChloramphenicol / chemical synthesis* Chloramphenicol / pharmacology Escherichia coli / drug effects Kinetics Microbial Sensitivity Tests Structure-Activity Relationship …
WebAug 14, 2015 · ANTIBIOTICS 1.CHLORAMPHENICOL 2.MACROLIDES. 2. INTRODUCTION Antimicrobial drugs differ from all others in that they are designed to inhibit the growth or to kill the infecting organism and to have minimal effect or nil effect on the recipient. This type of therapy which is administered for treating systemic infections that … WebJun 30, 2024 · CHLORAMPHENICOL • Chloramphenicol is a broad spectrum antibiotic that inhibits bacterial protein synthesis by binding to 50s ribosomal subunit. • It was originally isolated from cultures of Streptomyces. ... The SlideShare family just got bigger. Enjoy access to millions of ebooks, audiobooks, magazines, and more from Scribd.
WebMay 7, 2024 · Chloramphenicol. 1. Prepared by: Dr Touseef. 2. CHLORAMPHENICOL Broad spectrum antibiotic Obtained from Streptomyces venezuelae. 3. ANTIMICROBIAL SPECTRUM Broad …
WebApr 10, 2024 · Conjugation and excretion of chloramphenicol is inefficient in the newborn: larger doses produce gray baby syndrome Sulfonamides displace bilirubin from protein binding sites— can cause kernicterus in the neonate because their blood- brain barrier is more permeable Tetracyclines deposit in the developing teeth and bone— discolour and … small business insurance by the hourWebJun 7, 2024 · 30. Fluoroquinolones Inhibits bacterial DNA gyrase which results in relaxation of supercoiled DNA, promoting DNA strand breakage. 1st Generation : Nalidixic acid 2nd Generation: Norfloxacin, Ciprofloxacin 3rd Generation: Levofloxacin 4th Generation: Moxifloxacin effective against gram-negative organisms. 31. small business insurance brokersWebMar 9, 2016 · Mechanism of Action Macrolide is a protein synthesis inhibitor. Generally it is bacteriostatic in action but acts as bacteriocidal at higher dose. Macrolides bind to 50S ribosomal sub-unit Inhibit polypeptide chain elongation & protein synthesis inhibition Result in inhibition of growth & multiplication. 10. 11. small business insurance brokers near mesome beasts 2019 english subtitlesWebFeb 25, 2016 · Inhibiton of bacterial growth is even seen when Conc of drug falls below MIC. REFLECTS time required by bacteria to return to normal growth. PAE is most significant with drugs that act by inhibiting bacterial protein synthesis or DNA synthesis. (Amino, Fluro, tetracycline, chloramphenicol, rifampicin. some beasley families of the colonial southWebSep 4, 2011 · Why Gray baby syndrome occurs in neonates ? Inability of neonate to metabolise & excrete chloramphenicol due to deficiency of glucuronosyl transferase At higher concentration it inhibits electron transport in liver, heart, skeletal muscle some bearingWebApr 20, 2010 · 22 slides Slideshows for you Tetracycline uptu • 73.6k views Betalactam antibiotics Dr Pralhad Patki • 38.8k views Chaloramphenicol as an antibiotic Muhammad Mudassir • 7.6k views … some beasts 2019 english